This textbook offers a foundational practical handbook on handling multiplicity, difference and diversity for healthcare professions. The first part deals with the social dynamics of pluralistic societies as well as economic flexibility, demographic change, and trends in mobility, migration and civil rights. The second part discusses “transitory categories”, using the example of disappearing terms such as “foreign cultures”, “second generation”, “religion” and “disability”. The third part focusses on “exclusion” through stigma, misanthropy and non-recognition as well as on basic and human rights. The meaning of transcategorical competence at different ages, different living environments and fields of practice is described in the fourth part, in articles on female circumcision, traumatization, migrant children and ageing. The fifth part is dedicated to healthcare provision, with a particular focus on women and men with experience of migration, on people with cognitive impairment and mental disorders and experience of migration. In the sixth part, various communication aspects in dealing with variation and difference are discussed.